黄体生成素β亚基

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Luteinizing hormone beta polypeptide
黄体生成素β多肽
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 LHB; CGB4; LSH-B; hLHB
扩展标识 遗传学：152780 鼠基因：96782 同源基因：81806 GeneCards: LHB Gene
RNA表达模式
PBB GE LHB 214471 x at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 3972 16866
Ensembl ENSG00000104826 ENSMUSG00000038194
UniProt P01229 G3X9G6
mRNA序列 NM_000894 NM_008497
蛋白序列 NP_000885 NP_032523
基因位置 Chr 19:
49.52 – 49.52 Mb		 Chr 7:
45.42 – 45.42 Mb
PubMed查询 [1] [2]
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黄体生成素β亚基（英语：Luteinizing hormone subunit beta 或 lutropin subunit beta ）是一种由人类基因LHB 编码的蛋白质[1][2]。

目录

基因

该基因位于19号染色体q13.3，编码黄体生成素的β亚基[2] In equines, this subunit is encoded by the same gene as the beta subunit of chorionic gonadatropin, subunits which are identical.[3]。

功能

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit (this protein) which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.[2]

临床意义

Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.[2]

参考文献

  1. ↑ Sairam MR, Li CH. Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. Biochim Biophys Acta. Feb 1976, 412 (1): 70–81. PMID 1191677. 
  2. ↑ 2.0 2.1 2.2 2.3 Entrez Gene: LHB luteinizing hormone beta polypeptide. 
  3. ↑ Sherman GB, Wolfe MW, Farmerie TA, Clay CM, Threadgill DS, Sharp DC, Nilson JH. A single gene encodes the beta-subunits of equine luteinizing hormone and chorionic gonadotropin. Mol. Endocrinol.. June 1992, 6 (6): 951–9. doi:10.1210/me.6.6.951. PMID 1379674. 


延伸阅读

  • Keutmann HT, Hua QX, Weiss MA. Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy. Mol. Endocrinol.. 1992, 6 (6): 904–13. doi:10.1210/me.6.6.904. PMID 1495492. 
  • Weiss J, Axelrod L, Whitcomb RW, et al.. Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone. N. Engl. J. Med.. 1992, 326 (3): 179–83. doi:10.1056/NEJM199201163260306. PMID 1727547. 
  • Weisshaar G, Hiyama J, Renwick AG, Nimtz M. NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. Eur. J. Biochem.. 1991, 195 (1): 257–68. doi:10.1111/j.1432-1033.1991.tb15702.x. PMID 1991473. 
  • Jameson JL, Lindell CM, Habener JF. Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. DNA. 1986, 5 (3): 227–34. doi:10.1089/dna.1986.5.227. PMID 2424697. 
  • Keutmann HT, Charlesworth MC, Mason KA, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC304579/ A receptor-binding region in human choriogonadotropin/lutropin beta subunit]. Proc. Natl. Acad. Sci. U.S.A.. 1987, 84 (7): 2038–42. doi:10.1073/pnas.84.7.2038. PMID 3470775. PMC 304579. 
  • Shome B, Parlow AF. The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH). J. Clin. Endocrinol. Metab.. 1973, 36 (3): 618–21. doi:10.1210/jcem-36-3-618. PMID 4685398. 
  • Closset J, Hennen G, Lequin RM. Human luteinizing hormone. The amino acid sequence of the subunit. FEBS Lett.. 1973, 29 (2): 97–100. doi:10.1016/0014-5793(73)80534-4. PMID 4719207. 
  • Talmadge K, Vamvakopoulos NC, Fiddes JC. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. Nature. 1984, 307 (5946): 37–40. doi:10.1038/307037a0. PMID 6690982. 
  • Beitins IZ, Axelrod L, Ostrea T, et al.. Hypogonadism in a male with an immunologically active, biologically inactive luteinizing hormone: characterization of the abnormal hormone. J. Clin. Endocrinol. Metab.. 1981, 52 (6): 1143–9. doi:10.1210/jcem-52-6-1143. PMID 6785294. 
  • Berger P, Kranewitter W, Madersbacher S, et al.. Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis. FEBS Lett.. 1994, 343 (3): 229–33. doi:10.1016/0014-5793(94)80561-X. PMID 7513655. 
  • Keutmann HT, Rubin DA. A subunit interaction site in human luteinizing hormone: identification by photoaffinity cross-linking. Endocrinology. 1993, 132 (3): 1305–12. doi:10.1210/en.132.3.1305. PMID 7679977. 
  • Herrlich A, Kühn B, Grosse R, et al.. Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. J. Biol. Chem.. 1996, 271 (28): 16764–72. doi:10.1074/jbc.271.28.16764. PMID 8663226. 
  • Muyan M, Furuhashi M, Sugahara T, Boime I. The carboxy-terminal region of the beta-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers. Mol. Endocrinol.. 1997, 10 (12): 1678–87. doi:10.1210/me.10.12.1678. PMID 8961276. 
  • Roy AC, Liao WX, Chen Y, et al.. Identification of seven novel mutations in LH beta-subunit gene by SSCP. Mol. Cell. Biochem.. 1997, 165 (2): 151–3. PMID 8979264. 
  • Liao WX, Roy AC, Chan C, et al.. A new molecular variant of luteinizing hormone associated with female infertility. Fertil. Steril.. 1998, 69 (1): 102–6. doi:10.1016/S0015-0282(97)00445-7. PMID 9457942. 
  • O'Connor JF, Kovalevskaya G, Birken S, et al.. The expression of the urinary forms of human luteinizing hormone beta fragment in various populations as assessed by a specific immunoradiometric assay. Hum. Reprod.. 1998, 13 (4): 826–35. doi:10.1093/humrep/13.4.826. PMID 9619532. 
  • Takahashi K, Kurioka H, Ozaki T, et al.. Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients. Hum. Reprod.. 1999, 13 (12): 3338–44. doi:10.1093/humrep/13.12.3338. PMID 9886510. 
  • Elter K, Erel CT, Cine N, et al.. Role of the mutations Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome. Fertil. Steril.. 1999, 71 (3): 425–30. doi:10.1016/S0015-0282(98)00491-9. PMID 10065776. 
  • Jiang M, Pakarinen P, Zhang FP, et al.. A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence. Hum. Mol. Genet.. 1999, 8 (11): 2037–46. doi:10.1093/hmg/8.11.2037. PMID 10484773. 

参考来源

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