促甲状腺激素β亚基

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Thyroid stimulating hormone, beta
促甲状腺激素β亚基
标识
代号 TSHB; TSH-B; TSH-BETA
扩展标识 遗传学：188540 鼠基因：98848 同源基因：463 GeneCards: TSHB Gene
直系同源体
物种 人类 鼠类
Entrez 7252 22094
Ensembl ENSG00000134200 ENSMUSG00000027857
UniProt P01222 P12656
mRNA序列 NM_000549 NM_001165939
蛋白序列 NP_000540 NP_001159411
基因位置 Chr 1:
115.57 – 115.58 Mb		 Chr 3:
102.78 – 102.78 Mb
PubMed查询 [1] [2]
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促甲状腺激素β亚基（英语：Thyroid stimulating hormone, beta，简称TSHB）是一个由人类基因TSHB 编码的蛋白质[1][2]。

目录

功能

促甲状腺激素（TSH）是由两个亚基非共价连接而成的糖蛋白，其α亚基为该类激素所共有，而β亚基则是独有的[3]。

另见

参考文献

  1. ↑ Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD. Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species. J. Biol. Chem.. September 1988, 263 (25): 12538–42. PMID 2457586. 
  2. ↑ Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K. The structure of the human thyrotropin beta-subunit gene. Gene. December 1988, 73 (2): 489–97. doi:10.1016/0378-1119(88)90513-6. PMID 3243440. 
  3. ↑ Entrez Gene: TSHB. 

延伸阅读

  • Bonomi M, Proverbio MC, Weber G, et al.. Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene.. J. Clin. Endocrinol. Metab.. 2001, 86 (4): 1600–4. doi:10.1210/jc.86.4.1600. PMID 11297590. 
  • Vuissoz JM, Deladoëy J, Buyukgebiz A, et al.. New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism.. J. Clin. Endocrinol. Metab.. 2001, 86 (9): 4468–71. doi:10.1210/jc.86.9.4468. PMID 11549695. 
  • Karges B, LeHeup B, Schoenle E, et al.. Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe.. Horm. Res.. 2004, 62 (3): 149–55. doi:10.1159/000080071. PMID 15297803. 
  • Kabadi UM, Premachandra BN. Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function?. Endocr Pract. 2007, 13 (6): 615–9. PMID 17954417. 
  • Miyai S, Yoshimura S, Iwasaki Y, et al.. Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line.. Cell Tissue Res.. 2005, 322 (2): 269–77. doi:10.1007/s00441-005-0033-z. PMID 16133148. 
  • Pierce JG. Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones.. Endocrinology. 1971, 89 (6): 1331–44. doi:10.1210/endo-89-6-1331. PMID 5002675. 
  • Atzmon G, Barzilai N, Surks MI, Gabriely I. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2795660/ Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity]. J. Clin. Endocrinol. Metab.. 2009, 94 (12): 4768–75. doi:10.1210/jc.2009-0808. PMID 19837933. PMC 2795660. 
  • Landa I, Ruiz-Llorente S, Montero-Conde C, et al.Gibson, Greg. . [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2727793/ The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors]. PLoS Genet.. 2009, 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMID 19730683. PMC 2727793. 
  • Pohlenz J, Dumitrescu A, Aumann U, et al.. Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene. J. Clin. Endocrinol. Metab.. 2002, 87 (1): 336–9. doi:10.1210/jc.87.1.336. PMID 11788671. 
  • Miyoshi I, Kasai N, Hayashizaki Y. [Structure and regulation of human thyroid-stimulating hormone (TSH) gene]. Nippon Rinsho. 1994, 52 (4): 940–7. PMID 8196184. 
  • Borck G, Topaloglu AK, Korsch E, et al.. Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect. J. Clin. Endocrinol. Metab.. 2004, 89 (8): 4136–41. doi:10.1210/jc.2004-0494. PMID 15292359. 
  • Comings DE, Gade-Andavolu R, Gonzalez N, et al.. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Clin. Genet.. 2000, 58 (5): 375–85. doi:10.1034/j.1399-0004.2000.580508.x. PMID 11140838. 
  • Gerhard DS, Wagner L, Feingold EA, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/ The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)]. Genome Res.. 2004, 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. PMC 528928. 
  • Clark AG, Glanowski S, Nielsen R, et al.. Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. Science. 2003, 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302. 
  • Loinder K, Söderström M. An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene. J. Steroid Biochem. Mol. Biol.. 2005, 97 (4): 322–7. doi:10.1016/j.jsbmb.2005.06.031. PMID 16216492. 
  • Luttrell LM. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Mol. Biotechnol.. 2008, 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029. 
  • Strausberg RL, Feingold EA, Grouse LH, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/ Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences]. Proc. Natl. Acad. Sci. U.S.A.. 2002, 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. PMC 139241. 
  • Brumm H, Pfeufer A, Biebermann H, et al.. Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect. J. Clin. Endocrinol. Metab.. 2002, 87 (10): 4811–6. doi:10.1210/jc.2002-020297. PMID 12364478. 
  • Benhadi N, Wiersinga WM, Reitsma JB, et al.. Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death. Eur. J. Endocrinol.. 2009, 160 (6): 985–91. doi:10.1530/EJE-08-0953. PMID 19273570. 
  • Schaefer JS, Klein JR. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2689139/ A novel thyroid stimulating hormone β-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid]. Gen. Comp. Endocrinol.. 2009, 162 (3): 241–4. doi:10.1016/j.ygcen.2009.04.006. PMID 19364510. PMC 2689139. 

促甲状腺激素β亚基引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。

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