黏液素
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黏液素（英语：Mucins，或简称黏素）是一类高分子量蛋白家族，且高度糖基化（属于糖缀合物），在大部分后生动物的上皮组织中都有表达[1] Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers.[1]。They often take an inhibitory role.[1] Some mucins are associated with controlling mineralization, including nacre formation in mollusks,[2] calcification in echinoderms[3] and bone formation in vertebrates.[4] They bind to pathogens as part of the immune system. Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer.[5]
Although some mucins are membrane-bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, most mucins are secreted onto mucosal surfaces or secreted to become a component of saliva.
目录 |
基因
通过cDNA克隆发现了至少19个人类黏素基因——MUC1、MUC2、MUC3A、MUC3B、MUC4、MUC5AC、MUC5B、MUC6、MUC7、MUC8、MUC12、MUC13、MUC15、MUC16、MUC17、MUC19和MUC20[6]。
主要分泌于呼吸道的黏素是MUC5AC和MUC5B，而MUC2主要分泌于小肠，在呼吸道中也有出现。
另见
参考文献
- ↑ 1.0 1.1 1.2 doi:10.1016/S0070-2153(07)80006-8
本引用来源将会在数十分钟后自动完成。您可以检查英文对应模板或手动扩充 - ↑ doi:10.1074/jbc.M003006200
本引用来源将会在数十分钟后自动完成。您可以检查英文对应模板或手动扩充 - ↑ doi:10.1080/713713622
本引用来源将会在数十分钟后自动完成。您可以检查英文对应模板或手动扩充 - ↑ RJ Midura, VC Hascall. Bone sialoprotein–a mucin in disguise?. Glycobiology. 1996, 6 (7): 677–81. doi:10.1093/glycob/6.7.677. PMID 8953277.
- ↑ Niv Y. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2703837/ MUC1 and colorectal cancer pathophysiology considerations]. World J. Gastroenterol.. April 2008, 14 (14): 2139–41. doi:10.3748/wjg.14.2139. PMID 18407586. PMC 2703837.
- ↑ Perez-Vilar, J; Hill, RL. Mucin Family of Glycoproteins. Encyclopedia of Biological Chemistry (Lennarz & Lane, EDs.). Oxford: Academic Press/Elsevier. 2004, 2: 758–764.
- Ali M, Hutton D, Wilson J, Pearson J. Major Secretory Mucin Expression in Chronic Sinusitis. Otolaryngology - Head and Neck Surgery. September 2005, 133 (3): 423–428. doi:10.1016/j.otohns.2005.06.005. PMID 16143194.
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