载脂蛋白A1

Apolipoprotein A-I; 载脂蛋白A1
	; PDB rendering based on 1av1.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1AV1, 1GW3, 1GW4, 1ODP, 1ODQ, 1ODR, 2A01, 3J00, 3K2S, 3R2P
标识
代号	APOA1; MGC117399
扩展标识	遗传学：107680 鼠基因：88049 同源基因：47900 ChEMBL: 5984 GeneCards: APOA1 Gene
基因本体论描述
分子功能	· beta-amyloid binding; · protein binding; · phospholipid binding; · phospholipid transporter activity; · high-density lipoprotein particle binding; · cholesterol binding; · cholesterol transporter activity; · enzyme binding; · apolipoprotein receptor binding; · apolipoprotein A-I receptor binding; · identical protein binding; · lipase inhibitor activity; · phosphatidylcholine-sterol O-acyltransferase activator activity; · high-density lipoprotein particle receptor binding;
细胞成分	· extracellular region; · extracellular space; · nucleus; · early endosome; · endoplasmic reticulum lumen; · cytosol; · plasma membrane; · endocytic vesicle; · cytoplasmic vesicle; · very-low-density lipoprotein particle; · high-density lipoprotein particle; · spherical high-density lipoprotein particle; · secretory granule lumen;
生物过程	· retinoid metabolic process; · regulation of protein phosphorylation; · endothelial cell proliferation; · platelet degranulation; · negative regulation of cytokine secretion involved in immune response; · lipid metabolic process; · phosphatidylcholine biosynthetic process; · cholesterol biosynthetic process; · G-protein coupled receptor signaling pathway; · response to nutrient; · blood coagulation; · phototransduction, visible light; · cholesterol metabolic process; · glucocorticoid metabolic process; · negative regulation of tumor necrosis factor-mediated signaling pathway; · positive regulation of cholesterol esterification; · negative regulation of very-low-density lipoprotein particle remodeling; · peripheral nervous system axon regeneration; · protein oxidation; · peptidyl-methionine modification; · lipid storage; · platelet activation; · regulation of intestinal cholesterol absorption; · cholesterol transport; · adrenal gland development; · organ regeneration; · regulation of Cdc42 protein signal transduction; · cholesterol efflux; · phospholipid efflux; · negative regulation of heterotypic cell-cell adhesion; · high-density lipoprotein particle remodeling; · high-density lipoprotein particle assembly; · high-density lipoprotein particle clearance; · lipoprotein metabolic process; · lipoprotein biosynthetic process; · response to drug; · cholesterol homeostasis; · blood vessel endothelial cell migration; · response to estrogen stimulus; · reverse cholesterol transport; · cellular lipid metabolic process; · small molecule metabolic process; · negative regulation of interleukin-1 beta secretion; · negative regulation of inflammatory response; · protein stabilization; · positive regulation of hydrolase activity; · positive regulation of transferase activity; · transmembrane transport; · phospholipid homeostasis; · negative regulation of lipase activity; · negative regulation of cell adhesion molecule production; · negative regulation of response to cytokine stimulus; · triglyceride homeostasis; · cholesterol import;
	Sources: Amigo / QuickGO
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A+医学百科 >> 载脂蛋白A1

载脂蛋白A1（英语：Apolipoprotein A-I）为附着于高密度脂蛋白及乳靡小球上的载脂蛋白，可以活化卵磷脂-胆固醇酰基转移酶（Lecithin Cholesterol Acyltransferase）；当高密度脂蛋白运送组织中多余的胆固醇回到肝脏细胞中时，载脂蛋白A1同时也可作为高密度脂蛋白的配体受基(ligand)。

参考来源

维基百科-载脂蛋白A1

出自A+医学百科 “载脂蛋白A1”条目 http://www.a-hospital.com/w/%E8%BD%BD%E8%84%82%E8%9B%8B%E7%99%BDA1 转载请保留此链接

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