CD4受体
A+医学百科 >> CD4受体 |
CD4受体 | |||||||||
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structure of t-cell surface glycoprotein cd4, monoclinic crystal form | |||||||||
鉴定 | |||||||||
标志 | CD4-extrcel | ||||||||
Pfam(蛋白家族查询站) | PF09191 | ||||||||
InterPro(蛋白数据整合站) | IPR015274 | ||||||||
SCOP(蛋白结构分类数据站) | 1cid | ||||||||
OPM家族(膜蛋白方向) | 230 | ||||||||
OPM蛋白(膜蛋白方向) | 2klu | ||||||||
CDD(保守域数据站) | cd07695 | ||||||||
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CD4受体,全称“表面抗原分化簇4受体”(Cluster of Differentiation 4 receptors),是辅助T细胞的表面标记(surface markers)之一,也是辅助T细胞行使其功能的重要受体。当抗原呈递细胞(主要是巨噬细胞、棘状细胞及B细胞本身)将外来病菌分解,把抗原与主要组织相容性复合体结合后,呈递给辅助T细胞(即与辅助T细胞表面的CD4受体结合),辅助T细胞再接着刺激B细胞产生抗体,此即体液性免疫反应的基本过程。
目录 |
资料
常用单克隆抗体或代号:T4,Leu3a 主要表达细胞:Tsub,Msub,Thysub T细胞 分子质量(kDa)和结构:gp55(IgSF) 功 能:与MCHn类分子结合,信号转导,HIV受体
参见
参考文献
延伸阅读
- Miceli MC, Parnes JR. Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol.. Advances in Immunology. 1993, 53: 59–122. doi:10.1016/S0065-2776(08)60498-8. ISBN 978-0-12-022453-1. PMID 8512039.
- Geyer M, Fackler OT, Peterlin BM. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1083955/ Structure–function relationships in HIV-1 Nef]. EMBO Rep.. 2001, 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741. PMC 1083955.
- Greenway AL, Holloway G, McPhee DA, et al.. HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. J. Biosci.. 2004, 28 (3): 323–35. doi:10.1007/BF02970151. PMID 12734410.
- Bénichou S, Benmerah A. [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]. Med Sci (Paris). 2003, 19 (1): 100–6. doi:10.1051/medsci/2003191100. PMID 12836198.
- Leavitt SA, SchOn A, Klein JC, et al.. Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm. Curr. Protein Pept. Sci.. 2004, 5 (1): 1–8. doi:10.2174/1389203043486955. PMID 14965316.
- Tolstrup M, Ostergaard L, Laursen AL, et al.. HIV/SIV escape from immune surveillance: focus on Nef. Curr. HIV Res.. 2004, 2 (2): 141–51. doi:10.2174/1570162043484924. PMID 15078178.
- Hout DR, Mulcahy ER, Pacyniak E, et al.. Vpu: a multifunctional protein that enhances the pathogenesis of human immunodeficiency virus type 1. Curr. HIV Res.. 2005, 2 (3): 255–70. doi:10.2174/1570162043351246. PMID 15279589.
- Joseph AM, Kumar M, Mitra D. Nef: "necessary and enforcing factor" in HIV infection. Curr. HIV Res.. 2005, 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
- Anderson JL, Hope TJ. HIV accessory proteins and surviving the host cell. Current HIV/AIDS reports. 2005, 1 (1): 47–53. doi:10.1007/s11904-004-0007-x. PMID 16091223.
- Li L, Li HS, Pa, et al.. Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. Cell Res.. 2006, 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
- Stove V, Verhasselt B. Modelling thymic HIV-1 Nef effects. Curr. HIV Res.. 2006, 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
外部链接
- MeSH(医学主题词)上面的CD1+Antigen
- Mouse CD Antigen Chart
- Human CD Antigen Chart
- *Human Immunodeficiency Virus Glycoprotein 120
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参考来源
出自A+医学百科 “CD4受体”条目 http://www.a-hospital.com/w/CD4%E5%8F%97%E4%BD%93 转载请保留此链接
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