肌球蛋白轻链激酶

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{{protein | Name = [[MYLK|肌球蛋白轻多肽激酶]]，平滑肌 | caption = | image = | width = | HGNCid = 7590 | Symbol = [[MYLK]] | AltSymbols = | EntrezGene = 4638 | OMIM = 600922 | RefSeq = NM_053025 | UniProt = Q15746 | PDB = | ECnumber = 2.7.11.18 | Chromosome = 3 | Arm = q | Band = cen | LocusSupplementaryData = -q21 }} {{protein | Name = [[MYLK2|myosin light-chain kinase 2, skeletal muscle]] | caption = Crystal structure of the ''[[Scherffelia|S. dubia]]'' [[centrin]] / human skeletal muscle myosin light-chain complex.<ref name="3KF9">{{cite web |url=http://www.rcsb.org/pdb/explore/explore.do?structureId=3KF9 |title=RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex |format= |work= |accessdate=}}</ref> | image = SkMLCK.png | width = | HGNCid = 16243 | Symbol = [[MYLK2]] | AltSymbols = | EntrezGene = 85366 | OMIM = 606566 | RefSeq = NM_033118 | UniProt = Q9H1R3 | PDB = | ECnumber = | Chromosome = 20 | Arm = q | Band = 13.31 | LocusSupplementaryData = }} {{protein | Name = [[MYLK3|myosin light-chain kinase 3]], cardiac | caption = | image = | width = | HGNCid = 29826 | Symbol = [[MYLK3]] | AltSymbols = | EntrezGene = 91807 | OMIM = 612147 | RefSeq = NM_182493 | UniProt = Q32MK0 | PDB = | ECnumber = | Chromosome = 16 | Arm = q | Band = 11.2 | LocusSupplementaryData = }} {{protein | Name = 人类肌球蛋白轻链激酶 | caption = The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.<ref name="2X4F">{{cite web |url=http://www.rcsb.org/pdb/explore/explore.do?structureId=2X4F |title=RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156. |format= |work= |accessdate=}}</ref> | image = 2X4F.pdb.png | width = | HGNCid = 27972 | Symbol = [[MYLK4]] | AltSymbols = | EntrezGene = 340156 | OMIM = | RefSeq = NM_001012418 | UniProt = Q86YV6 | PDB = | ECnumber = | Chromosome = | Arm = 6 | Band = p | LocusSupplementaryData = 25.2 }} '''肌球蛋白轻链激酶'''（{{lang-en|Myosin light-chain kinase}}，'''MYLK''' 或 '''MLCK'''）是一类[[丝氨酸]]/[[苏氨酸]]特异性[[蛋白激酶]]，通过[[磷酸化]]来调节II型[[肌球蛋白]]的[[肌球蛋白轻链|轻链]]<ref name="pmid11758800">{{cite journal | author = Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K | title = Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction | journal = IUBMB Life | volume = 51 | issue = 6 | pages = 337–44 | year = 2001 | month = June | pmid = 11758800 | doi = 10.1080/152165401753366087| url = | issn = }}</ref>。 == 亚型 == 现存四种MLCK亚型<ref name="pmid12471243">{{cite journal | author = Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S | title = The protein kinase complement of the human genome | journal = Science | volume = 298 | issue = 5600 | pages = 1912–34 | year = 2002 | month = December | pmid = 12471243 | doi = 10.1126/science.1075762 | url = | issn = }}</ref>主要分布于不同[[肌细胞]]： * [[MYLK]] – 平滑肌 * [[MYLK2]] – 骨骼肌 * [[MYLK3]] – 心肌 * [[MYLK4]] – 未知 == 功能 == ==另见== * [[蛋白激酶A]] ==参考文献== {{reflist}} ==延伸阅读== {{refbegin | 2}} *{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} *{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal | author=Clayburgh DR, Rosen S, Witkowski ED, ''et al.'' |title=A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55506–13 |year= 2005 |pmid= 15507455 |doi= 10.1074/jbc.M408822200 | pmc=1237105 }} *{{cite journal | author=Wang F, Graham WV, Wang Y, ''et al.'' |title=Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. |journal=Am. J. Pathol. |volume=166 |issue= 2 |pages= 409–19 |year= 2005 |pmid= 15681825 |doi= 10.1016/S0002-9440(10)62264-X| pmc=1237049 }} *{{cite journal | author=Russo JM, Florian P, Shen L, ''et al.'' |title=Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. |journal=Gastroenterology |volume=128 |issue= 4 |pages= 987–1001 |year= 2005 |pmid= 15825080 |doi= 10.1053/j.gastro.2005.01.004| pmc=1237051 }} *{{cite journal | author=Shimizu S, Yoshida T, Wakamori M, ''et al.'' |title=Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. |journal=J. Physiol. (Lond.) |volume=570 |issue= Pt 2 |pages= 219–35 |year= 2006 |pmid= 16284075 |doi= 10.1113/jphysiol.2005.097998 | pmc=1464317 }} *{{cite journal | author=Kim MT, Kim BJ, Lee JH, ''et al.'' |title=Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells. |journal=Am. J. Physiol., Cell Physiol. |volume=290 |issue= 4 |pages= C1031–40 |year= 2006 |pmid= 16306123 |doi= 10.1152/ajpcell.00602.2004 }} *{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} *{{cite journal | author=Connell LE, Helfman DM |title=Myosin light chain kinase plays a role in the regulation of epithelial cell survival. |journal=J. Cell. Sci. |volume=119 |issue= Pt 11 |pages= 2269–81 |year= 2007 |pmid= 16723733 |doi= 10.1242/jcs.02926 }} *{{cite journal | author=Seguchi O, Takashima S, Yamazaki S, ''et al.'' |title=A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. |journal=J. Clin. Invest. |volume=117 |issue= 10 |pages= 2812–24 |year= 2007 |pmid= 17885681 |doi= 10.1172/JCI30804 | pmc=1978424 }} {{refend}} ==外部链接== * {{MeshName|MYLK+protein,+human}} * {{MeshName|Myosin-Light-Chain+Kinase}} {{NLM content}} {{丝氨酸/苏氨酸特异性蛋白激酶类}} ==参考来源== *[http://zh.wikipedia.org/wiki/%E8%82%8C%E7%90%83%E8%9B%8B%E7%99%BD%E8%BD%BB%E9%93%BE%E6%BF%80%E9%85%B6 维基百科-肌球蛋白轻链激酶]

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